In first-half stoppage time, the Liverpool attacker scored from the penalty spot to give the Dutch team, led by Virgil van Dijk and featuring Ryan Gravenberch, a two-goal lead over their opponents, led by Dominik Szoboszlai.
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After the interval in Amsterdam, the home team added two more goals, with Gakpo and Gravenberch being substituted approximately ten minutes before the end of the game. Szoboszlai and Van Dijk ended the match.
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In another Nations League match, Wales drew 0-0 with Turkiye, and Lewis Koumas came off the bench late in the game.
Additionally, Trent Kone-Doherty came off the bench to assist as the Republic of Ireland defeated Azerbaijan 4-0, while Trey Nyoni made his England debut at that level as a substitute in a 2-1 victory over Bulgaria in the U19 European Championship qualifying.